Data · dataset · 2026
Genetic susceptibility in the relative maternal protection from type 1 diabetes
Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.2337/figshare.33619168.v1
<p dir="ltr"><b>Objective:</b> Type 1 diabetes is half as common in offspring of affected mothers versus fathers.
Description
We investigated whether selective loss of fetuses with high genetic risk during type 1 diabetes pregnancy explains this relative protection.</p><p dir="ltr"><b>Research Design and Methods:</b> In 6942 TEDDY cohort live births, we compared genetic susceptibility by type 1 diabetes-affected family member and tested if it explained maternal protection from diabetes or its preclinical stages.</p><p dir="ltr"><b>Results: </b>The GRS2x did not differ between children with affected mothers (<i>P=</i>0.36) or siblings (<i>P=</i>0.27) versus fathers.
Relative maternal protection from type 1 diabetes and islet autoimmunity (IA) was observed with GRS2x adjustment (diabetes HR: 0.50, <i>P</i>=0.01; IA HR: 0.38, <i>P</i>=0.006) and without adjustment but not during progression from IA to diabetes. This protection wanes after age 6 years.</p><p dir="ltr"><b>Conclusions:</b> Intrauterine exposure to type 1 diabetes offers relative protection from IA during early childhood and is not explained by genetic susceptibility differences.</p>
Links
Where it is published
- DOI doi.org/10.2337/figshare.33619168.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Life Sciences · Life Sciences · Life Sciences · Medicine & Health · Medicine & Health · Medicine & Health
- Inferred from text
- Genetics 70%
Provenance · 3 source records, 15 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/33619168 | 12 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/33619168 | 12 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/33619168 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].anzsrc:group:3105 | enrichment · zivahub uct ac za | taxonomy-embedding@1.1.0 | title+keywords+description (70%) |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/rights |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |