Data · dataset · 2026
Whole-genome evolutionary dynamics of human parainfluenza virus type 3 in Shanghai, China, 2016–2024
Listed in ScienceDB
Human parainfluenza virus type 3 (HPIV-3) is a major viral cause of acute respiratory infection (ARI), particularly in children, the elderly, and immunocompromised individuals.
Description
However, the limited availability of whole-genome data has impeded progress in viral evolution, vaccines, antiviral treatments, and effective preventive strategies. To address this gap, we conducted a comprehensive molecular evolutionary analysis of HPIV-3 based on whole-genome sequences obtained from clinical samples in Shanghai between 2016 and 2024.
A total of 50 complete genomes were generated through a novel one-step amplification protocol combined with next-generation sequencing. Phylogenetic analysis revealed that all strains belonged to genotype C3. Time-scaled phylogenetic analysis estimated the tMRCA of HPIV-3 to be around 1925.55, earlier than previous estimates based on partial HN sequences, and revealed a stable population size prior to 1990 followed by two phases of sustained demographic expansion.
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Recombination events were detected in the HN gene and multiple other regions of the HPIV-3 genome. Entropy and selection pressure analyses demonstrated that the L gene showed the highest sequence variability and was the primary target of positive selection, emphasizing its role in viral evolution and adaptation. This study provides a comprehensive whole-genome–based evolutionary analysis of HPIV-3 in China and underscores the value of full-genome sequencing for accurate lineage classification, molecular surveillance, and a deeper understanding of viral dynamics.
Our findings highlight the importance of integrating genomic data into epidemiological monitoring to inform the development of vaccines and antiviral strategies.
Links
Where it is published
- DOI doi.org/10.57760/sciencedb.36547 ↗
DOI / persistent id · from scidb cn
Catalogue records · 1
- OAI-PMH record scidb.cn/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=10.57760%2… ↗
metadata API · from scidb cn
Topics
- From keywords
- Earth & Environmental Science · Engineering · Humanities · Life Sciences · Social Science
- Inferred from text
- Genome sequencing 65% · Sequencing 75%
Provenance · 1 source records, 11 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ScienceDB | 10.57760/sciencedb.36547 | 9 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[field].local:field:earth-environmental | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:engineering | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:humanities | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:social-science | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[modality].local:modality:genome-sequencing | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[modality].local:modality:sequencing | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (75%) |
| description | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/description |
| license_text | source · scidb cn | connector:scidb_cn@1.0.0 | |
| publication_date | source · scidb cn | connector:scidb_cn@1.0.0 | |
| title | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/title |