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Data · dataset · 2024

An ergometer to measure muscle bioenergetics with magnetic resonance techniques

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Applying magnetic resonance methods to measure the metabolic response in exercise poses a technical challenge because the construction of the ergometer must use non-magnetic components and assess work in the confined space of a magnet bore.

Description

The present report details the fabrication of a non-magnetic ergometer for use in a standard Siemens 3 Tesla (T) spectrometer. Using the ergometer, researchers can measure the 31P NMR signals during leg muscle exercise and exercise recovery.

In particular, the phosphocreatine (PCr) kinetics during exercise recovery reflects the mitochondrial oxidative capacity, and the inorganic phosphate (Pi) signal tracks the cellular pH. The ergometer allows for a personalized, and variable load to be lifted leading to total work performed across study participants being similar regardless of their leg strength. The ergometer then enables a standardized magnetic resonance spectroscopy (MRS) comparison of leg muscle bioenergetics between study participants.

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Basic medicine
Provenance · 1 source records, 12 field assertions
SourceKeyLast seenRaw
DataCite10.5061/dryad.08kprr59v12 d agoJSON v1
FieldAssertionExtractorEvidence
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