Data Sheet 1_A pilot genome-wide association study of ischemic heart disease with co-occurring arterial hypertension in a Kazakh cohort.docx

The strongest SNP association was observed for rs1511924 at chromosome 16 mapped to the ZFHX3 gene (OR = 0.49, 95% CI = 0.37–0.66; P = 1.00 × 10⁻⁶). Post-imputation GWAS supported the same locus with rs12598508 (P = 4.93 × 10⁻⁷) and rs1511924 (P = 5.15 × 10⁻⁷) among the strongest signals, although neither reached the genome-wide significance. Secondary MAGMA and KGWAS analyses did not provide stable evidence for additional loci.</p>Conclusion<p>To our knowledge, this is the first pilot GWAS focused on IHD with co-occurring arterial hypertension in a Kazakh cohort.

Although no Bonferroni-significant SNP associations were identified, the ZFHX3 region emerged as the strongest suggestive candidate locus and requires independent replication. Larger Central Asian cohorts and population-specific reference resources are required to validate these findings.</p>