Table · dataset · 2026
<p>AUC calibration parameters.</p>
Listed in figshare and Loughborough Research Repository — shown once because both records carry DOI 10.1371/journal.pone.0358765.t002
<div><p>Carotid plaque (CP) is a surrogate marker of cardiovascular disease, and high-risk morphology significantly increases the risk of stroke.
Description
The aim of this study was to develop advanced machine learning (ML) models to predict the presence of CP in the general population. The study involved 693 participants from the Polish Longitudinal University Study – Bialystok PLUS, a representative sample of the local population.
The analysis used 460 OLINK protein biomarkers. The data were analysed using the BORUTA algorithm based on the random forest classifier method. We identified 42 significant biomarkers associated with CP, the most important of which were GDF-15, CDCP1, CHIT1, FLT3LG, CDH2 and CRTAC1.
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Interestingly, the top 6 biomarkers had a highly speculative or unresolved association with atherosclerosis. Next, we developed an ML-based CP fingerprint comprising 25 biomarkers, which showed good internal cross-validated discrimination in subjects aged 30–70 years. We also generated a network of interactions for the 42 biomarkers using STRING database modules, and performed a functional analysis to assess the biological significance of the interactions detected.
These results are hypothesis-generating and require external, prospective validation to identify cause-and-effect relationships.</p></div>
Links
Where it is published
- DOI doi.org/10.1371/journal.pone.0358765.t002 ↗
DOI / persistent id · from figshare com
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from figshare com
Topics
- From keywords
- Astronomy & Astrophysics · Biochemistry and cell biology · Biochemistry and cell biology · Cardiovascular disease · Cardiovascular disease · Chemistry · Chemistry · Computer Science & AI · Computer Science & AI · Earth & Environmental Science · Earth & Environmental Science · Economics & Finance · Economics & Finance · Engineering · Engineering · Humanities · Humanities · Life Sciences · Life Sciences · Materials Science · Mathematics & Statistics · Medicine & Health · Medicine & Health · Ocean & Atmospheric Science · Operator algebras and functional analysis · Operator algebras and functional analysis · Psychology & Behavioral Science · Social Science · Social Science
- Inferred from text
- Disease 75% · Longitudinal study 65%
Provenance · 2 source records, 36 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| figshare | oai:figshare.com:article/33988431 | 4 d ago | JSON v1 |
| Loughborough Research Repository | oai:figshare.com:article/33988431 | 3 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · figshare com | connector:figshare_com@1.0.0 | |
| concepts[disease].local:disease:cardiovascular-disease | mapping · repository lboro ac uk | vocabulary-mapper@1.0.0 | keywords['cardiovascular disease'] |
| concepts[disease].local:disease:cardiovascular-disease | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['cardiovascular disease'] |
| concepts[disease].local:disease:disease | enrichment · figshare com | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:field:490408 | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['functional analysis'] |
| concepts[field].anzsrc:field:490408 | mapping · repository lboro ac uk | vocabulary-mapper@1.0.0 | keywords['functional analysis'] |
| concepts[field].anzsrc:group:3101 | mapping · repository lboro ac uk | vocabulary-mapper@1.0.0 | keywords['Cell Biology'] |
| concepts[field].anzsrc:group:3101 | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['Cell Biology'] |
| concepts[field].local:field:astronomy | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:computer-science-ai | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:computer-science-ai | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:economics-finance | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:economics-finance | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:engineering | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:engineering | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:humanities | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:humanities | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:materials-science | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:mathematics-statistics | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:ocean-atmospheric | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:psychology-behavioral | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:social-science | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:social-science | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[method].local:method:longitudinal-study | enrichment · figshare com | keyword-concept-rules@1.0.0 | title+description (65%) |
| description | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/description |
| license | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/rights |
| publication_date | source · figshare com | connector:figshare_com@1.0.0 | |
| title | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/title |