Data · dataset · 2025
A study of alterations in DNA epigenetic modifications (5mC and 5hmC) influenced by simulated microgravity in human lymphoblastoid cells
Listed in NASA Data Portal
Here in this study we systematically examined the patterns of DNA methylation and hydroxy-methylation with its functional implications in gene regulation for the cultured TK6 lymphoblastoid cells upon exposure to micro-gravity conditions.
Description
The results reported here indicate that simulated microgravity alters methylation patterns in a limited way and subsequently the expression of genes involved in stress response like ATF3 FBXO17 MAP3K13 and VCL in TK6 cells.
Overall design: Examination of RNA-seq with 2 replicates each for 1 cell type
Links
Get the data
- genelab-data.ndc.nasa.gov /genelab/accession/GLDS-86 ↗
A study of alterations in DNA epigenetic modifications (5mC and 5hmC) influenced by simulated microgravity in human lymphoblastoid cells
download · from data nasa gov
Where it is published
- NASA Data Portal dataset page data.nasa.gov/dataset/a-study-of-alterations-in-dna-epigenetic-modifications… ↗
landing page · from data nasa gov
Catalogue records · 1
- CKAN API data.nasa.gov/api/3/action/package_show?id=3d84a9c2-c1b3-41f9-9348-3f0f11790… ↗
metadata API · from data nasa gov
Topics
- From keywords
- Engineering
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NASA Data Portal | 3d84a9c2-c1b3-41f9-9348-3f0f11790eb3 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[field].local:field:engineering | mapping · data nasa gov | connector:data_nasa_gov@1.0.0 | |
| concepts[modality].local:modality:rna-seq | enrichment · data nasa gov | keyword-concept-rules@1.0.0 | title+description (65%) |
| created_date | source · data nasa gov | connector:data_nasa_gov@1.0.0 | |
| description | source · data nasa gov | connector:data_nasa_gov@1.0.0 | /notes |
| license_text | source · data nasa gov | connector:data_nasa_gov@1.0.0 | |
| publication_date | source · data nasa gov | connector:data_nasa_gov@1.0.0 | |
| title | source · data nasa gov | connector:data_nasa_gov@1.0.0 | /title |
| updated_date | source · data nasa gov | connector:data_nasa_gov@1.0.0 |