Data · dataset · 2026
<p>Demographics.</p>
Listed in NCL Data
<div> <p>Background</p><p>Medication adherence is a persistent challenge in the treatment of multidrug-resistant tuberculosis (MDR-TB) and HIV.
Description
Routine counseling notes are an underutilized source of information on patient adherence context.</p> <p>Methods</p><p>We applied natural language processing (NLP) to routine counseling notes from a randomized controlled trial of MDR-TB/HIV treatment in South Africa. Topics were derived using topic modeling; notes were semantically matched to topics and clustered using K-means.
We fitted linear mixed-effects (LME) regression models with participant-level random intercepts and five-fold cross-validation to model adherence to bedaquiline (BDQ) and antiretroviral therapy (ART), measured using cellular-enabled electronic dose monitor (EDM). Cosine similarity scores, cluster assignments, and temporal proximity to counseling sessions were included as covariates. Model fit was assessed using mean absolute error (MAE) and root mean square error (RMSE).</p> <p>Results</p><p>We analyzed 327 counseling notes from 76 participants.
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Six thematic clusters were derived: substance use, logistical barriers, limited social support, side effect management, financial stability, and financial insecurity/low support. LME showed modest fit. For BDQ adherence, MAE was 0.158 (95% CI 0.113–0.204) and RMSE 0.208 (95% CI 0.133–0.283).
For ART, MAE was 0.180 (95% CI 0.170–0.191) and RMSE 0.224 (95% CI 0.202–0.246). Cluster membership was not associated with adherence. In contrast, temporal proximity to counseling was more consistently associated with adherence.
Adherence was highest immediately following counseling sessions. Both BDQ and ART adherence declined during the intermediate period (β=−0.048, p = 0.001; β=−0.031, p = 0.022, respectively), and ART adherence declined further in the period preceding the next session (β=−0.032, p = 0.020).</p> <p>Conclusion</p><p>NLP methods structured routine counseling notes into interpretable, adherence-related themes. Temporal proximity to counseling sessions was consistently associated with longitudinal BDQ and ART adherence.
These findings offer preliminary insights into adherence dynamics and generate hypotheses about the role of counseling session timing in adherence support.</p></div>
Links
Where it is published
- DOI doi.org/10.1371/journal.pone.0355696.t001 ↗
DOI / persistent id · from data ncl ac uk
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from data ncl ac uk
Topics
- From keywords
- Cancer · Earth & Environmental Science · Evolutionary biology · Humanities · Infectious diseases · Life Sciences · Medicine & Health · Social Science · Virology
- Inferred from text
- Longitudinal study 65%
Provenance · 1 source records, 15 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCL Data | oai:figshare.com:article/34071400 | 20 h ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · data ncl ac uk | connector:data_ncl_ac_uk@1.0.0 | |
| concepts[disease].local:disease:cancer | mapping · data ncl ac uk | vocabulary-mapper@1.0.0 | keywords['Cancer'] |
| concepts[field].anzsrc:field:310706 | mapping · data ncl ac uk | vocabulary-mapper@1.0.0 | keywords['Virology'] |
| concepts[field].anzsrc:field:320211 | mapping · data ncl ac uk | vocabulary-mapper@1.0.0 | keywords['Infectious Diseases'] |
| concepts[field].anzsrc:group:3104 | mapping · data ncl ac uk | vocabulary-mapper@1.0.0 | keywords['Evolutionary Biology'] |
| concepts[field].local:field:earth-environmental | mapping · data ncl ac uk | connector:data_ncl_ac_uk@1.0.0 | |
| concepts[field].local:field:humanities | mapping · data ncl ac uk | connector:data_ncl_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · data ncl ac uk | connector:data_ncl_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · data ncl ac uk | connector:data_ncl_ac_uk@1.0.0 | |
| concepts[field].local:field:social-science | mapping · data ncl ac uk | connector:data_ncl_ac_uk@1.0.0 | |
| concepts[method].local:method:longitudinal-study | enrichment · data ncl ac uk | keyword-concept-rules@1.0.0 | title+description (65%) |
| description | source · data ncl ac uk | connector:data_ncl_ac_uk@1.0.0 | /metadata/dc/description |
| license | source · data ncl ac uk | connector:data_ncl_ac_uk@1.0.0 | /metadata/dc/rights |
| publication_date | source · data ncl ac uk | connector:data_ncl_ac_uk@1.0.0 | |
| title | source · data ncl ac uk | connector:data_ncl_ac_uk@1.0.0 | /metadata/dc/title |