Effects of phloretin, ritonavir, indinavir and Bay-876 on glucose transport during peritoneal dialysis in Sprague-Dawley rats

It is as yet unknown via which GLUTs such transport occurs and whether transport occurs in a trans-cellular fashion. This study was undertaken to elucidate (i) whether glucose may be transferred in a trans-cellular fashion across peritoneal cells and (ii) via which GLUTs glucose transport may be partly mediated during PD.

The main study was performed in thirty-two Sprague-Dawley rats in which PD was performed by instillation of 20 mL 2.3% glucose PD fluid which was allowed to dwell for 60 min. Animals were given an IV infusion of [18F]-deoxyglucose allowing us to monitor glucose transport in both directions: from the dialysate to the circulation and vice versa. Animals received either no treatment (control), or received intra-peritoneal phloretin (50 mg/L), ritonavir (60 mg/L), or BAY-876 (25 mg/L).