<p>Comparison experiment table.</p>

An attention pooling mechanism aggregated node-level representations into graph level representations for sample classification, and a two layer fully connected network, following activation and regularization, produced predicted probabilities. Furthermore, we provided interpretable analyses at the gene level using GNNExplainer. The results were validated through virtual knockout techniques.

The eight screened genes, Fibronectin 1 (<i>FN1</i>), Claudin 2 (<i>CLDN2</i>), Interleukin-33 (<i>IL-33</i>), Matrix Metallopeptidase 1 (<i>MMP1</i>), Stanniocalcin 2 (<i>STC2</i>), Insulin-Like Growth Factor-Binding Protein 7 (<i>IGFBP7</i>), NADPH Oxidase 4 (<i>NOX4</i>), and Secreted Frizzled Related Protein 1 (<i>SFRP1</i>), were all found to be associated with overall survival (OS) in CRC. In this study, eight molecules closely related to the development of colorectal adenocarcinoma were screened out, and they may be diagnostic biomarkers of colorectal cancer.

These genes affect the prognosis of patients by participating in biological processes such as remodeling of extracellular mechanisms, and are of great significance for preventing the carcinogenesis of adenoma.</p></div>