Data · dataset · 2025
靶向cGAMP介导的STING激活的药物
Listed in ScienceDB
激活环磷酸鸟苷（GMP）-单磷酸腺苷（AMP）合酶-干扰素基因刺激剂（cGAS-STING）通路是一种新兴的肿瘤免疫治疗策略，通过产生I型干扰素激活抗肿瘤免疫并实现肿瘤杀伤。2'，3'-环磷酸鸟苷-单磷酸腺苷（2'，3'-cGAMP）是STING通路的天然激活信号分子，由cGAS感应细胞质中的异常DNA产生。许多研究表明，增加cGAMP在肿瘤部位的生物利用度可诱导免疫细胞浸润和激活，显著改善抑制性肿瘤微环境。本文综述了小分子药物和材料系统在增强原位cGAMP免疫效能方面的先进进展。这为通过激活STING通路提高抗肿瘤免疫治疗的有效性提供了新的视角。
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Where it is published
- DOI doi.org/10.57760/sciencedb.j00217.06765 ↗
DOI / persistent id · from scidb cn
Catalogue records · 1
- OAI-PMH record scidb.cn/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=10.57760%2… ↗
metadata API · from scidb cn
Topics
- From keywords
- Earth & Environmental Science · Engineering · Humanities · Life Sciences · Social Science
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ScienceDB | 10.57760/sciencedb.j00217.06765 | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[field].local:field:earth-environmental | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:engineering | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:humanities | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:social-science | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| description | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/description |
| license_text | source · scidb cn | connector:scidb_cn@1.0.0 | |
| publication_date | source · scidb cn | connector:scidb_cn@1.0.0 | |
| title | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/title |