Data · dataset · 2026
Towards the Limits of Spatial Resolution in Preclinical PET: Prototype Validation and High-Sensitivity Dual-Layer Extension
Listed in ScienceDB
High spatial resolution and sensitivity are paramount in preclinical positron emission tomography (PET).
Description
Thicker scintillators improve detection efficiency but increase depth-of-interaction (DOI) parallax, whereas thinner scintillators reduce depth uncertainty at the expense of sensitivity. We developed and experimentally evaluated a compact PET scanner utilizing 0.579-mm-pitch, 5-mm-thick lutetium yttrium orthosilicate (LYSO) crystal arrays (0.497 × 0.497 × 5 mm3) and investigated a higher-sensitivity dual-layer architecture with discrete DOI encoding through simulation.
The prototype achieved an energy resolution (full width at half maximum, FWHM) of 13.43% ± 1.95% at 511 keV, a peak sensitivity of 0.87% (350–650 keV window), a peak noise-equivalent count rate of 6.02 kcps, and a scatter fraction of 8.92%. Filtered back-projection yielded mean radial, tangential, and axial spatial resolutions (FWHM) of 0.90, 0.86, and 0.69 mm, respectively, reaching a minimum axial FWHM of 0.48 mm.
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Micro-Derenzo phantom imaging demonstrated sub-0.5-mm contrast modulation, with mean peak-to-valley ratios of 1.65 and 1.48 for the 0.45- and 0.40-mm rod sectors. In 18F-NaF murine imaging, the computed tomography (CT)-referenced structural similarity index was 0.79, versus 0.67 for a commercial scanner. Three configurations retained the prototype as the inner-layer detector ring, adding outer crystals with thicknesses of 5, 7.5, or 10 mm, and expanded axial coverage.
Simulated peak sensitivity increased monotonically to 3.10%, 4.27%, and 5.36% (up to a 4.36× gain over the baseline), while spatial resolution degradation remained constrained due to a high fraction (71.1%–85.7%) of coincidences retaining inner-layer interaction endpoints. These results validate the prototype’s state-of-the-art spatial resolution and establish a viable architectural blueprint for next-generation DOI-PET systems.
Links
Where it is published
- DOI doi.org/10.57760/sciencedb.0129b ↗
DOI / persistent id · from scidb cn
Catalogue records · 1
- OAI-PMH record scidb.cn/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=10.57760%2… ↗
metadata API · from scidb cn
Topics
- From keywords
- Earth & Environmental Science · Engineering · Humanities · Life Sciences · Social Science
- Inferred from text
- Computed tomography 75% · Imaging 75% · Simulation 75%
Provenance · 1 source records, 13 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ScienceDB | 10.57760/sciencedb.0129b | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:engineering | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:humanities | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:social-science | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[method].local:method:simulation | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:ct | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:imaging | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (75%) |
| description | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/description |
| license | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/rights |
| publication_date | source · scidb cn | connector:scidb_cn@1.0.0 | |
| title | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/title |