The first general protocol for N -monoalkylation of sulfamate esters: benign synthesis of N -alkyl Topiramate (anticonvulsant drug) derivatives

This reaction proceeded efficiently using alkyl halides, benzyl halides and α-halo ketones as the electrophile in the presence of KF-Al 2 O 3 as a cost-effective and robust catalyst. This approach provides new access to N -monoalkylated Topiramate (anticonvulsant drug) derivatives which are potentially of great importance in medicinal chemistry.