Transcriptomic profiling of brain regions and primary fibroblasts from BRD1 haploinsufficient Göttingen minipigs

To investigate the transcriptional consequences of BRD1 haploinsufficiency in a translational large-animal model, we performed RNA sequencing of multiple brain regions and primary fibroblasts from BRD1 haploinsufficient (BRD1+/-) and wild-type Göttingen minipigs. The study identifies tissue- and brain region-specific transcriptional alterations associated with reduced BRD1 function and forms part of a broader multimodal characterization of the neurodevelopmental and systemic consequences of BRD1 haploinsufficiency.