Dataset for: Drug loading and release from PVDF-TrFE fiber mats and changes in morphology and electrical impedance on model electrodes

Wetting was promoted by supplementing 30% ethanol to the conductive solution. Electrical impedance increased with fiber mat application and with increasing electrospinning duration and polymer concentration. Dexamethasone release from the fiber mats was slow, with relative releases not exceeding 4% after two weeks for any of the concentrations or variants investigated.

Greater dexamethasone release was observed from blend fiber mats than from the corresponding coaxial variants. <b>Discussion: </b>The increase in impedance caused by the additional fiber mat layer can be modulated by varying fiber mat morphology. Ethanol can promote wetting, although its use is limited to applications in which biocompatibility is not required. Although long-term release studies are needed to further evaluate drug release from the loaded fiber mats, the short-term results indicate their potential for sustained drug delivery.

Overall, surface modification of cochlear implant electrodes with electrospun fiber mats may provide a strategy to mitigate the electrical insulation associated with post-implantation connective tissue formation.</p>