Data · dataset · 2014
The transcription factor p53: Not a repressor, solely an activator
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The predominant function of the tumor suppressor p53 is transcriptional regulation.
Description
It is generally accepted that p53-dependent transcriptional activation occurs by binding to a specific recognition site in promoters of target genes. Additionally, several models for p53-dependent transcriptional repression have been postulated.
Here, we evaluate these models based on a computational meta-analysis of genome-wide data. Surprisingly, several major models of p53-dependent gene regulation are implausible. Meta-analysis of large-scale data is unable to confirm reports on directly repressed p53 target genes and falsifies models of direct repression.
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This notion is supported by experimental re-analysis of representative genes reported as directly repressed by p53. Therefore, p53 is not a direct repressor of transcription, but solely activates its target genes. Moreover, models based on interference of p53 with activating transcription factors as well as models based on the function of ncRNAs are also not supported by the meta-analysis.
As an alternative to models of direct repression, the meta-analysis leads to the conclusion that p53 represses transcription indirectly by activation of the p53-p21-DREAM/RB pathway.
Links
Where it is published
- Repository landing page tandf.figshare.com/articles/dataset/The_transcription_factor_p53_Not_a_repressor_… ↗
landing page · from DataCite
- Repository landing page tandf.figshare.com/articles/dataset/The_transcription_factor_p53_Not_a_repressor_… ↗
landing page · from DataCite
- DOI doi.org/10.6084/m9.figshare.1232210.v2 ↗
DOI / persistent id · from DataCite
- DOI doi.org/10.6084/m9.figshare.1232210 ↗
DOI / persistent id · from DataCite
Documentation and papers
- Creative Commons Attribution 4.0 International creativecommons.org/licenses/by/4.0/legalcode ↗
license · from DataCite
- IsSupplementTo 10.4161/15384101.2014.949083 doi.org/10.4161/15384101.2014.949083 ↗
publication · from DataCite
Catalogue records · 4
- DataCite API api.datacite.org/dois/10.6084/m9.figshare.1232210 ↗
metadata API · from DataCite
- DataCite API api.datacite.org/dois/10.6084/m9.figshare.1232210.v2 ↗
metadata API · from DataCite
- DataCite Commons commons.datacite.org/doi.org/10.6084/m9.figshare.1232210 ↗
catalogue entry · from DataCite
- DataCite Commons commons.datacite.org/doi.org/10.6084/m9.figshare.1232210.v2 ↗
catalogue entry · from DataCite
Topics
- Stated by source
- Biological sciences · Biological sciences · Health sciences · Health sciences
- From keywords
- Bioinformatics and computational biology · Genetics · Life Sciences · Life Sciences · Plant biology
- Inferred from text
- Cancer 65%
Related
- Inverse of has versionThe transcription factor p53: Not a repressor, solely an activator
- Possibly the same asThe transcription factor p53: Not a repressor, solely an activator
Provenance · 2 source records, 15 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| DataCite | 10.6084/m9.figshare.1232210 | 15 d ago | JSON v1 |
| DataCite | 10.6084/m9.figshare.1232210.v2 | 15 d ago | JSON v1 |
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