Data · dataset · 2026
TNF inhibitors for the prevention of Alzheimer’s disease
Listed in ZivaHub and Deakin Research Online and DMU Figshare and UCL Research Data Repository — shown once because both records carry DOI 10.17034/32631690.v1
In recent years, genome-wide association studies have identified polymorphisms in several genes which implicate the role of inflammation in the development and progression of Alzheimer's disease (AD).
Description
This is of particular relevance in rheumatoid arthritis (RA), a chronic inflammatory autoimmune disease, as these patients have higher levels of systemic inflammation than the general population. If AD is driven by inflammation, then RA may be the ideal model in which to observe the accelerated effects of systemic inflammation on cognitive decline for future interventional trials.
Moreover, there have been several inflammatory biomarkers which have been found to be peripherally elevated in both diseases including tumour necrosis factor-alpha (TNFa), a proinflammatory cytokine which has been associated with an increased rate of neurodegeneration and risk of conversion from mild cognitive impairment (MCI) to AD dementia. This led to the development of a hypothesis which suggested that reduction in peripheral TNFa via TNF inhibitors (TNFi) may slow or prevent cognitive decline associated with AD.
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This thesis aimed to test this hypothesis by using preliminary data from the rheumatoid arthritis medication and memory study (RESIST), an 18-month observational study which aims to compare the rate of cognitive decline between TNFi and conventional synthetic anti-rheumatic drugs (csDMARDs) in patients with both RA and MCI. While analysis of screening data was able to demonstrate high prevalence of cognitive impairment in this RA population, analysis of preliminary longitudinal data found little evidence of a relationship between TNFi and better cognitive performance after 6/12 months.
This analysis will be repeated using 18-month data when available which will more fully describe the relationship between TNFi and cognitive outcomes. Nevertheless, this preliminary research is a valuable contribution in a topic that is largely under researched and will help to inform future longitudinal studies of TNFi as a preventative treatment for AD.
Links
Where it is published
- DOI doi.org/10.17034/32631690.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Medicine & Health · Medicine & Health · Medicine & Health · Medicine & Health · Psychology & Behavioral Science · Psychology & Behavioral Science · Psychology & Behavioral Science · Psychology & Behavioral Science
- Inferred from text
- Cancer 65% · Disease 75% · Longitudinal study 65%
Provenance · 4 source records, 19 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/32631690 | 12 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/32631690 | 12 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/32631690 | 12 d ago | JSON v1 |
| UCL Research Data Repository | oai:figshare.com:article/32631690 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[disease].local:disease:cancer | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[disease].local:disease:disease | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:psychology-behavioral | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:psychology-behavioral | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:psychology-behavioral | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:psychology-behavioral | mapping · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| concepts[method].local:method:longitudinal-study | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (65%) |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |