Omics · study · 2026
Loss of CsrA in Acinetobacter baumannii leads to lethal dysregulation of alanine metabolism
Listed in NCBI GEO
We identified the transcription factor Lrp in a genetic screen to identify suppressors in an A. baumannii csrA mutant background.
Description
The CsrA null phenotype presents in part as a failure to grow in rich media, which we found was alleviated in strains lacking Lrp. As a transcription factor, we hypothesized that Lrp controls the expression of on ore more genes that represents the actual suppressor of the CsrA mutant strain.
To test this hypothesis, we conducted RNA-seq to determine the repetoire of genes that are under regulatory control of CsrA in A. baumannii strain AB5075.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE313nnn/GSE313900 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE313900 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1387212 ncbi.nlm.nih.gov/bioproject/PRJNA1387212 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE313900 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |