Data · dataset · 2025
Gelatin/Polyethylene glycol/g-C3N4 hydrogel with olive oil as a sustainable and biocompatible nanovehicle for targeted delivery of 5-fluorouracil
Listed in e-cienciaDatos
In this project, a novel, sustainable and pH-sensitive nanocomposite was designed for the targeted delivery of 5-fluorouracil (5-FU) against breast cancer cells.
Description
The nanodelivery system is based on graphitic carbon nitride (g-C3N4) coated with Gelatin (G)/Polyethylene glycol (PEG) biopolymers, and was prepared by W/O/W double emulsion technique using olive oil and span 80 surfactant. Successful loading of 5-FU into the nanovehicle was confirmed by infrared spectroscopy and X-ray diffraction analyses.
VDynamic light scattering corroborated the monodispersity of the nanocarriers, with a typical size between 250 and 300 nm. Scanning electron microscopy images revealed the homogeneity of the nanocomposite and its spherical shape. The average zeta potential was +35.4 mV, demonstrating the good stability of the nanocomposite.
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The drug loading (47%) and encapsulation efficiency (89%) were higher than those reported for other 5-FU nanocarriers. A continuous and controlled 5-FU release from the nanovehicle was observed, and the release rate at pH 5.4 (simulating a cancerous environment) was higher than at pH 7.4 (physiological conditions). Kinetic studies suggested a diffusion controlled mechanism of 5-FU release from the nanocarrier in an acidic environment, while an anomalous transport prevails at neutral pH.
The MTT assay revealed that G/PEG/g-C3N4 had a significant cytotoxicity on MCF-7 breast cancer cells. Flow cytometry indicated that G/PEG/g-C3N4/5-FU led to much higher apoptotic percentage than free 5-FU, while the free drug showed higher percentage of necroptotic cells.
Links
Where it is published
- Dataverse dataset page edatos.consorciomadrono.es/dataset.xhtml?persistentId=doi%3A10.21950%2F6ODJOP ↗
landing page · from edatos consorciomadrono es
- DOI doi.org/10.21950/6odjop ↗
DOI / persistent id · from edatos consorciomadrono es
Catalogue records · 1
- Dataverse API edatos.consorciomadrono.es/api/datasets/:persistentId/?persistentId=doi%3A10.21950%2F6ODJ… ↗
metadata API · from edatos consorciomadrono es
Topics
- Stated by source
- Química
- Inferred from text
- Cancer 75% · Image 65% · Medicinal and biomolecular chemistry 72% · Microscopy 75%
Provenance · 1 source records, 11 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| e-cienciaDatos | doi:10.21950/6ODJOP | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[disease].local:disease:cancer | enrichment · edatos consorciomadrono es | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:group:3404 | enrichment · edatos consorciomadrono es | taxonomy-embedding@1.1.0 | title+keywords+description (72%) |
| concepts[field].dataverse_subject:qu-mica | source · edatos consorciomadrono es | connector:edatos_consorciomadrono_es@1.0.0 | /subjects |
| concepts[modality].local:modality:image | enrichment · edatos consorciomadrono es | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[modality].local:modality:microscopy | enrichment · edatos consorciomadrono es | keyword-concept-rules@1.0.0 | title+description (75%) |
| created_date | source · edatos consorciomadrono es | connector:edatos_consorciomadrono_es@1.0.0 | |
| description | source · edatos consorciomadrono es | connector:edatos_consorciomadrono_es@1.0.0 | /description |
| publication_date | source · edatos consorciomadrono es | connector:edatos_consorciomadrono_es@1.0.0 | |
| title | source · edatos consorciomadrono es | connector:edatos_consorciomadrono_es@1.0.0 | /name |
| updated_date | source · edatos consorciomadrono es | connector:edatos_consorciomadrono_es@1.0.0 | |
| version_label | source · edatos consorciomadrono es | connector:edatos_consorciomadrono_es@1.0.0 |