Data · dataset · 2026
<p>Primary single-cell localization and matched-null calibration of perturbation scores.</p>
Listed in UCL Research Data Repository
<p>(A) Cellular composition of the OA and OP single-cell datasets used for contextual analysis.
Description
(B) Candidate expression in OA fibroblasts, OA macrophages, OP bone marrow mesenchymal stromal cells, and OP osteoclast precursors. Tile labels show mean log-normalized expression, and color indicates within-gene relative expression.
(C) Matched-null Z scores for 39 evaluable candidate-compartment pairs. Each observed score was compared with scores from 200 control genes matched on mean log-normalized expression and wild-type weighted out-degree within the corresponding 600- or 601-gene network stratum. Asterisks indicate global FDR < 0.05, and NE indicates that no evaluable result was obtained.
Read the rest (2 more)
(D) Five leading calibrated pairs shown separately for OA and OP. One-sided empirical P values used the plus-one correction and were adjusted across all 39 evaluable pairs. OA, osteoarthritis; OP, osteoporosis; BM-MSC, bone marrow mesenchymal stromal cell; FDR, false discovery rate.
External quality-control sensitivity results, including cell-retention statistics and comparison with the primary candidate-compartment findings, are provided in <a href="plosone.org/article/info:doi/10.1371/journal.pone.0359583#pone.0359583.s016" target="_blank">S7 Fig</a> and <a href="plosone.org/article/info:doi/10.1371/journal.pone.0359583#pone.0359583.s008" target="_blank">S8 Table</a>.</p>
Links
Where it is published
- DOI doi.org/10.1371/journal.pone.0359583.g006 ↗
DOI / persistent id · from rdr ucl ac uk
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from rdr ucl ac uk
Topics
- From keywords
- Biochemistry and cell biology · Earth & Environmental Science · Genetics · Immunology · Infectious diseases · Life Sciences · Medicine & Health
- Inferred from text
- Tabular 65%
Provenance · 1 source records, 13 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| UCL Research Data Repository | oai:figshare.com:article/34048619 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| concepts[field].anzsrc:field:320211 | mapping · rdr ucl ac uk | vocabulary-mapper@1.0.0 | keywords['Infectious Diseases'] |
| concepts[field].anzsrc:group:3101 | mapping · rdr ucl ac uk | vocabulary-mapper@1.0.0 | keywords['Cell Biology'] |
| concepts[field].anzsrc:group:3105 | mapping · rdr ucl ac uk | vocabulary-mapper@1.0.0 | keywords['Genetics'] |
| concepts[field].anzsrc:group:3204 | mapping · rdr ucl ac uk | vocabulary-mapper@1.0.0 | keywords['Immunology'] |
| concepts[field].local:field:earth-environmental | mapping · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| concepts[modality].local:modality:tabular | enrichment · rdr ucl ac uk | keyword-concept-rules@1.0.0 | title+description (65%) |
| description | source · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | /metadata/dc/description |
| license | source · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | /metadata/dc/rights |
| publication_date | source · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| title | source · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | /metadata/dc/title |