Supplemental data from: Tobacco and marijuana induce adverse effects on cardiac function and Platelet activity and reduce tissue preservation following myocardial infarction

Myocardial infarct size, normalized to area-at-risk, was assessed following MI after repeated (4-week) exposure. Single exposure to tobacco smoke or JUUL aerosol reduced left ventricular ejection fraction relative to pre-exposure. Acute marijuana smoke exposure similarly impaired left ventricular function assessed by hemodynamics.

Single exposure to tobacco, marijuana, and placebo marijuana smoke increased collagen-induced platelet aggregation, with more pronounced responses in females, whereas repeated (2-week) exposure to smoke/aerosol from tobacco cigarettes, JUUL, IQOS, and placebo marijuana increased platelet aggregation across groups. Notably, repeated (4-week) exposure to tobacco smoke/aerosol or marijuana smoke prior to MI reduced myocardial tissue preservation, resulting in greater infarct size post-MI.

These findings indicate that individual tobacco and marijuana smoking and vaping similarly impair cardiac function, enhance platelet reactivity, and reduce myocardial tolerance to ischemia/reperfusion injury.