Quorum-Sensing Model for the Pyoverdine Expression in P. aeruginosa.

The model consists of 114 species, among which are small molecules, proteins, genes whit their mRNAs, and nine complexes (Sheet 1 of the excel file). Also, the QS model has 103 reactions, including DNA transcription, mRNA translation, protein complex formation, inhibition reactions, and molecule-molecule interactions with positive, negative, or unknown influences (Figure 1).

Each interaction and reaction in the QS model has the kinetic constant value established in the literature (Sheet 2 of the excel file). The values of the kinetic constants not reported by the literature were assumed according to the ranges of values of the kinetic constants reported for similar molecules. For the construction of the model, 114 ODEs were generated, and an elemental kinetic based on the Mass Action Law was assumed for all reactions that describe the system.