Excel · study · 2026
Transcriptomics and experiments verified that astaxanthin reduces the apoptosis of nerve cells in ischemic stroke by inhibiting the toll-like receptor signaling pathway
Listed in NCBI GEO
Background and Objective.
Description
Inflammation is an important pathological process in ischemic stroke (IS). Astaxanthin (ATX) is a natural product with neuroprotection effects.
However, the mechanism of ATX on anti-inflammatory after IS is not clear. The aim of this study was to investigate the mechanism of ATX on anti-inflammatory after IS. Methods.
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Male Sprague-Dawley rats were used to establish a model of middle cerebral artery occlusion (MCAO) on one side, and were pre-treated with gavage of ATX for 7 days. One day after MCAO, the brain tissues were collected. Transcriptomic sequencing, flow cytometry, brain water content, western blot, HE staining and ELISA were analyzed to evaluated the brain damage.
Results. ATX treatment has improved the neurological deficits, reduced brain edema, and apoptosis. Also, ATX has reduced inflammation and apoptosis related proteins such as TLR4, MyD88, NFκB, IL1β, IL6, Cyt C and Caspsae3.
Conclusions. ATX can improve nerve damage after IS, and these protective effects were realized by anti-inflammatory and anti-apoptosis. This protective mechanism involves the TLR4/MyD88/NF-κB signaling pathway
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE324nnn/GSE324069 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE324069 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1433388 ncbi.nlm.nih.gov/bioproject/PRJNA1433388 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Rattus norvegicus
- From keywords
- Life Sciences
- Inferred from text
- Sequencing 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE324069 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10116 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |