Novel lidocaine containing intraperitoneal implants for the improved control of post-surgical pain

Thus, pre-formulations of eutectic mixtures (EMs) of LID with lipids (mono and di-carboxylic fatty acids or fatty alcohols) prepared in chapter 3 were further applied in three different platforms in order to improve the physical stability of drug and prolong the therapeutic effect of LID.The LID-lipids were characterised using DSC, PXRD, HSM and FTIR for EMs screening.

LID-monocarboxylic FAs and LID-fatty alcohols formed EMs whereas LID-dicarboxylic FAs did not; via HSM studies, only LID-dicarboxylic FAs showed multiple eutectic interface zones in Koffler contact method. Moreover, LID-short chain monocarboxylic FAs systems were the only binary systems which interface zones did not crystallise even at temperatures lower as -90 oC for the systems were low crystallisation tendency. Thus, LID-monocarboxylic FAs and LID-fatty alcohols binary mixtures were carried forward to design novel delivery systems.