Data · dataset · 2026
Analysis code for: Proteome-wide Mendelian Randomization Identifies Therapeutic Targets for Ischemic Stroke
Listed in ScienceDB
This dataset contains the complete Python analysis code for the manuscript "Proteome-wide Mendelian Randomization Identifies Therapeutic Targets for Ischemic Stroke" (Translational Stroke Research, under revision).
Description
The pipeline screens 589 conditionally independent cis-pQTL sentinel variants from the INTERVAL study against four GIGASTROKE ischemic stroke outcomes (AIS, LAA, CES, SVD) using Wald-ratio Mendelian randomization, followed by approximate-Bayes-factor colocalization (coloc.abf formulation re-implemented in Python), replication in the deCODE pQTL cohort via the IEU OpenGWAS API, single-cell expression validation in the MultiVINE-seq human brain vascular atlas, phenome-wide safety screening, and Open Targets drug repurposing.
All analyses use publicly available summary statistics. The README documents data sources, execution order, and errata fixed during peer review.
Links
Where it is published
- DOI doi.org/10.57760/sciencedb.013ua ↗
DOI / persistent id · from scidb cn
Catalogue records · 1
- OAI-PMH record scidb.cn/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=10.57760%2… ↗
metadata API · from scidb cn
Topics
- From keywords
- Earth & Environmental Science · Engineering · Humanities · Life Sciences · Medicine & Health · Social Science
- Inferred from text
- Pharmacology and pharmaceutical sciences 72%
Provenance · 1 source records, 11 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ScienceDB | 10.57760/sciencedb.013ua | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[field].anzsrc:group:3214 | enrichment · scidb cn | taxonomy-embedding@1.0.0 | title+keywords+description (72%) |
| concepts[field].local:field:earth-environmental | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:engineering | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:humanities | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:social-science | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| description | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/description |
| license_text | source · scidb cn | connector:scidb_cn@1.0.0 | |
| publication_date | source · scidb cn | connector:scidb_cn@1.0.0 | |
| title | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/title |