Allylation of C-, N-, and O-Nucleophiles via a Mechanochemically-Driven Tsuji–Trost Reaction Suitable for Late-Stage Modification of Bioactive Molecules

Analytical Data and Compound Numbering (in paper numbering vs. ELN entries) for the Publication entitled: "Allylation of C-, N-, and O-Nucleophiles via a Mechanochemically-Driven Tsuji–Trost Reaction Suitable for Late-Stage Modification of Bioactive Molecules" The paper was published on 2023-22-06 in Angewandte Chemie International Edition Angew. Chem. Int.

Ed. 2024, 63, e202314637 DOI: 10.1002/anie.202314637 Authors: Johanna Templ and Michael Schnürch Funded by the Austrian Science Fund (FWF, project number P33064-N) Context and methodology In this Publication, we describe a mechanochemical, solvent-free protocol for Tsuji–Trost allylation of O -, N -, and C -Nucleophiles using nontoxic, solid allyl trimethylammonium chloride as alternative allylating agent. This method features fast reaction kinetics, very low catalyst loadings, high yields, mild conditions, and high functional group tolerance.