Correlation analysis between serum 25-hydroxyvitamin D level and the severity of allergic rhinitis in children

Furthermore, the 25(OH)D levels, immunoglobulin E (IgE) levels and visual analogue scale (VAS) scores were compared between children with mild AR and those with moderate or severe AR. Pearson correlation analysis was conducted to assess the correlation of serum 25(OH)D levels with IgE levels and VAS scores. Receiver operating characteristic (ROC) curves were generated to evaluate the diagnostic efficacy of serum 25(OH)D levels in diagnosing AR and determining its severity. Results: The control group exhibited significantly higher 25(OH)D levels than the research group (P<0.05).

ROC curves were constructed to evaluate the diagnostic value of 25(OH)D in diagnosing AR, resulting in an area under the curve (AUC) of 0.781. In comparison to the moderate/severe group, the mild group demonstrated significantly lower IgE levels and obtained notably lower VAS scores (P<0.05). The ROC curve was generated to assess the diagnostic value of 25(OH)D in determining the severity of AR, yielding an AUC of 0.878.

The 25(OH)D levels exhibited a negative correlation with IgE levels and VAS scores (P<0.001). Conclusion: Due to its strong association with the severity of AR in children, serum 25(OH)D level holds significant clinical value for the diagnosis and evaluation of AR in children.