Data Sheet 1_Antispasmodic and analgesic strategies for renal colic in pregnancy: a comprehensive analysis.pdf

Four dimensions for the RCTs had a low risk of bias, with one dimension having “some concerns.” In network meta-analyses, phloroglucinol was most effective in relieving pain within 1 h, followed by progesterone, while anisodamine was least effective. Phloroglucinol caused the least side effects like nausea and dizziness compared to progesterone and anisodamine. In pairwise meta-analyses, phloroglucinol had a lower 6-h pain recurrence rate and fewer side effects like blurred vision and palpitations than anisodamine.

Variations in phloroglucinol dosage contributed to heterogeneity, but subgroup and sensitivity analyses confirmed result stability.</p>Conclusion<p>Phloroglucinol is the preferred treatment for renal colic pain during pregnancy due to its efficacy and safety. It can be combined with progesterone, but anisodamine is not advised. Further high-quality research is necessary to confirm this finding.</p>Clinical Trial Registration<p>crd.york.ac.uk/PROSPERO/view/CRD42022377502.</p>