Data Sheet 1_Analgesic effect of methadone constant rate infusion is not superior to fentanyl constant rate infusion in dogs after spinal surgery: a prospective, randomized, blinded, clinical trial.pdf

Multiple Mann–Whitney tests were used for the analysis of CMPS-SF scores and sedation scores. Vital parameters, between and within the groups, were analyzed using mixed-effects analysis and Dunnett’s multiple comparison test. The need for rescue analgesia was assessed via survival analysis.

The level of significance was set to α = 5%.</p>Results<p>In the postoperative period, six dogs in group M and four dogs in group F required rescue analgesia. CMPS-SF scores were not different between the groups M and F and did not change significantly over time within the treatment groups. Tactile sensory thresholds were not different between the groups M and F.</p>Clinical significance<p>Under the dosing regimens investigated, methadone did not provide superior postoperative analgesia compared to fentanyl.

From a clinical perspective, both drugs provided effective postoperative analgesia in this heterogeneous cohort of dogs following spinal surgery.</p>