Data · dataset · 2022
Figure 6
Listed in ScienceDB
FIGURE 6 | Exosomes transfer miR-92b-3p to promote SCLC migration and chemoresistance.
Description
(A) TEM images of exosomes isolated from SCLC cells. (B) The sizeand quantitation of exosomes isolated from SCLC cells were examined by nanoparticle tracking analysis.
(C) The levels of CD63 and TSG101 were detected bywestern blot. (D) Fluorescence microscopy images of SBC-3 cells after treatment with PKH26-labeled exosomes (green) stained with DAPI (blue). SBC-3 cells couldeffectively uptake the exosomes.
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(E) MiR-92b-3p and PTEN levels as detected by qRT-PCR. SCLC cells showed higher levels of miR-92b-3p and lower levels ofPTEN after they were incubated with exosomes. (F) SCLC cells displayed higher migration ability after incubation with exosomes.
(G) DDP treatment inhibited tumorgrowth, whereas this inhibition was reversed after combination therapy with exosomes. Compared with SBC-3 NC group, *P < 0.05, **P < 0.01, and ***P < 0.001.All experiments were performed independently three times. SCLC, small cell lung cancer and TEM, transmission electron microscopy.
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Where it is published
- DOI doi.org/10.57760/sciencedb.03081 ↗
DOI / persistent id · from scidb cn
Catalogue records · 1
- OAI-PMH record scidb.cn/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=10.57760%2… ↗
metadata API · from scidb cn
Topics
- From keywords
- Earth & Environmental Science · Engineering · Humanities · Life Sciences · Medicine & Health · Social Science
- Inferred from text
- Biochemistry and cell biology 71% · Cancer 75% · Image 65% · Microscopy 75%
Provenance · 1 source records, 15 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ScienceDB | 10.57760/sciencedb.03081 | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:group:3101 | enrichment · scidb cn | taxonomy-embedding@1.0.0 | title+keywords+description (71%) |
| concepts[field].local:field:earth-environmental | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:engineering | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:humanities | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:social-science | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[modality].local:modality:image | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[modality].local:modality:microscopy | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (75%) |
| description | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/description |
| license | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/rights |
| publication_date | source · scidb cn | connector:scidb_cn@1.0.0 | |
| title | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/title |