Data · dataset · 2026
Development and testing of a proof of concept Cathepsin S ProteaseTag activity-based immunoassay
Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.17034/32805719.v1
Cathepsin S (CatS) is an elastolytic cysteine protease involved in antigen presentation and is reportedly upregulated in diseases including rheumatoid arthritis (RA), acute respiratory distress syndrome (ARDS), chronic obstructive pulmonary disease (COPD), and cystic fibrosis (CF).
Description
Studies have shown increased CatS activity correlates with reduced lung function. This thesis developed highly potent and selective CatS inhibitors that were functionalised into activity-based probes (ABPs) for use in an immunoassay capable of detecting active CatS in complex patient samples.
The resulting assay successfully detected CatS in sputum from CF and COPD patients, highlighting its potential for earlier diagnosis and intervention in chronic lung diseases.<br><br><i>Thesis is embargoed until 31 July 2031.</i>
Links
Where it is published
- DOI doi.org/10.17034/32805719.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science
- Inferred from text
- Disease 75%
Provenance · 3 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/32805719 | 12 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/32805719 | 12 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/32805719 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |