Data · dataset · 2015
Tctex1d2 associates with short-rib polydactyly syndrome proteins and is required for ciliogenesis
Listed in DataCite
Short-rib polydactyly syndromes (SRPS) arise from mutations in genes involved in retrograde intraflagellar transport (IFT) and basal body homeostasis, which are critical for cilia assembly and function.
Description
Recently, mutations in WDR34 or WDR60 (candidate dynein intermediate chains) were identified in SRPS. We have identified and characterized Tctex1d2, which associates with Wdr34, Wdr60 and other dynein complex 1 and 2 subunits.
Tctex1d2 and Wdr60 localize to the base of the cilium and their depletion causes defects in ciliogenesis. We propose that Tctex1d2 is a novel dynein light chain important for trafficking to the cilium and potentially retrograde IFT and is a new molecular link to understanding SRPS pathology.
Links
Where it is published
- Repository landing page tandf.figshare.com/articles/dataset/Tctex1d2_associates_with_short_rib_polydactyl… ↗
landing page · from DataCite
- Repository landing page tandf.figshare.com/articles/dataset/Tctex1d2_associates_with_short_rib_polydactyl… ↗
landing page · from DataCite
- DOI doi.org/10.6084/m9.figshare.1378951 ↗
DOI / persistent id · from DataCite
- DOI doi.org/10.6084/m9.figshare.1378951.v2 ↗
DOI / persistent id · from DataCite
Documentation and papers
- Creative Commons Attribution 4.0 International creativecommons.org/licenses/by/4.0/legalcode ↗
license · from DataCite
- IsSupplementTo 10.4161/15384101.2014.985066 doi.org/10.4161/15384101.2014.985066 ↗
publication · from DataCite
Catalogue records · 4
- DataCite API api.datacite.org/dois/10.6084/m9.figshare.1378951.v2 ↗
metadata API · from DataCite
- DataCite API api.datacite.org/dois/10.6084/m9.figshare.1378951 ↗
metadata API · from DataCite
- DataCite Commons commons.datacite.org/doi.org/10.6084/m9.figshare.1378951.v2 ↗
catalogue entry · from DataCite
- DataCite Commons commons.datacite.org/doi.org/10.6084/m9.figshare.1378951 ↗
catalogue entry · from DataCite
Topics
- Stated by source
- Biological sciences · Biological sciences · Health sciences · Health sciences · Mathematics · Mathematics · Physical sciences · Physical sciences
- From keywords
- Biochemistry and cell biology · Genetics · Medicine & Health · Medicine & Health
Provenance · 2 source records, 18 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| DataCite | 10.6084/m9.figshare.1378951 | 12 d ago | JSON v1 |
| DataCite | 10.6084/m9.figshare.1378951.v2 | 12 d ago | JSON v1 |
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|---|---|---|---|
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| concepts[field].fos:health-sciences | source · DataCite | connector:datacite@1.0.0 | |
| concepts[field].fos:health-sciences | source · DataCite | connector:datacite@1.0.0 | |
| concepts[field].fos:mathematics | source · DataCite | connector:datacite@1.0.0 | |
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| concepts[field].local:field:medicine-health | mapping · DataCite | vocabulary-mapper@1.0.0 | keywords['Medicine'] |
| concepts[field].local:field:medicine-health | mapping · DataCite | vocabulary-mapper@1.0.0 | keywords['Medicine'] |
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| publication_date | source · DataCite | connector:datacite@1.0.0 | /data/attributes/dates |
| title | source · DataCite | connector:datacite@1.0.0 | /data/attributes/titles/0/title |
| updated_date | source · DataCite | connector:datacite@1.0.0 |