Data · dataset · 2026
A Target-Based Approach to Decipher the Microbiota-Modulating Effects of Glycyrrhizic Acid Using Click Chemistry-Enabled Sorting
Listed in ScienceDB
This project investigates the interaction between glycyrrhizic acid (GA), a bioactive small molecule derived from traditional Chinese medicine, and the gut microbiota in a DSS-induced colitis mouse model.
Description
The study integrates 16S rRNA gene sequencing, click chemistry-enabled bacterial labeling and sorting, shotgun metagenomic sequencing, and untargeted metabolomics to identify GA-associated gut bacteria and explore their potential functional contribution to intestinal barrier protection.
The datasets include fecal microbiota profiles from control, DSS model, and GA-treated mice; metagenomic profiles of GA-labeled/sorted bacterial populations; and LC-MS/MS-based metabolomic profiles of representative GA-associated bacterial strains cultured with or without GA.
Links
Where it is published
- DOI doi.org/10.57760/sciencedb.42864 ↗
DOI / persistent id · from scidb cn
Catalogue records · 1
- OAI-PMH record scidb.cn/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=10.57760%2… ↗
metadata API · from scidb cn
Topics
- From keywords
- Chemistry · Earth & Environmental Science · Engineering · Humanities · Life Sciences · Social Science
- Inferred from text
- Mass spectrometry 65% · Medicinal and biomolecular chemistry 73% · Sequencing 75%
Provenance · 1 source records, 14 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ScienceDB | 10.57760/sciencedb.42864 | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].anzsrc:group:3404 | enrichment · scidb cn | taxonomy-embedding@1.0.0 | title+keywords+description (73%) |
| concepts[field].local:field:chemistry | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:engineering | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:humanities | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:social-science | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[modality].local:modality:mass-spectrometry | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[modality].local:modality:sequencing | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (75%) |
| description | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/description |
| license_text | source · scidb cn | connector:scidb_cn@1.0.0 | |
| publication_date | source · scidb cn | connector:scidb_cn@1.0.0 | |
| title | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/title |