Gut Microbiota Was Reshaped in Bate-thalassemia Monkeys via the Blood-Gut Axis and Contributed to Gastrointestinal Symptoms

Further functional analysis indicated that gene knockout significantly altered several key metabolic pathways, including amino acid and energy metabolism. These integrated findings suggest that HBB mutants potentially affect host metabolism and immune responses by modulating interactions between the gut microbiota and its metabolites. This study, for the first time, demonstrates in non-human primates that Bate- thalassemia can influence gastrointestinal health by altering the homeostasis of the gut microbiota, and offers valuable references for understanding the potential mechanisms underlying Bate-thalassemia symptoms, highlighting the impact of host genetic variations on gut microbiome regulation.