Omics · study · 2026
Transcriptomic Classification and Developmental Mapping of Canine Acute Leukemia Reveal Distinct Myeloid and Lymphoid Subgroups
Listed in NCBI GEO
Canine acute leukemias are biologically heterogeneous hematopoietic malignancies whose molecular features remain incompletely defined.
Description
We performed bulk RNA sequencing of peripheral blood leukocytes from 110 dogs with acute leukemia together with 10 immunophenotypically normal peripheral blood controls and 5 immunophenotypically normal bone marrow controls. The study was designed to define transcriptional programs associated with canine acute leukemia, resolve myeloid- and lymphoid-associated molecular subgroups, compare leukemia profiles with normal hematopoietic reference populations, and evaluate conserved developmental and leukemogenic programs relevant to comparative leukemia biology.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE345nnn/GSE345838 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE345838 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1522206 ncbi.nlm.nih.gov/bioproject/PRJNA1522206 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75% · Zoology 72%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE345838 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3109 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (72%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |