Omics · study · 2026
Jejunal and pancreatic transcriptomic adaptations underpin enhanced performance in broilers fed sugarcane bagasse-supplemented diets
Listed in NCBI GEO
This study investigated the transcriptomic changes in the jejunum and pancreas of broiler chickens fed a diet supplemented with sugarcane bagasse (SB) to elucidate the physiological response of broilers to insoluble dietary fiber.
Description
Differentially expressed genes (DEGs) were identified (significant threshold at absolute log2 (fold change) ≥ 1 and P < 0.05) and functionally annotated using gene ontology (GO; gene counts ≥ 2 and P < 0.05 as significant) analysis.
Compared with the control broilers, SB-fed broilers presented significantly (P < 0.05) greater weight gain and improved feed conversion ratio at the end of the grower phase. A total of 41 (18 upregulated and 23 downregulated) jejunal and 125 (36 upregulated and 89 downregulated) pancreatic DEGs were identified from the differential expression analysis. The SB-fed broilers showed coordinated upregulation of DEGs involved in nutrient transport (TRPM3, SLC16A4, FFAR4, and RBP4A), epithelial integrity (WNT9A, GAL3ST2, TFF3, and AGR2), immune activation (DUOX2 and MHCY6), and growth regulation (POU1F1).
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Gene ontology enrichment further revealed significant activation of biological processes, including maintenance of the gastrointestinal epithelium, gastric acid secretion, sodium ion transport, and response to oxidative stress, in the pancreatic tissue. These findings reveal that SB supplementation triggers beneficial, tissue-specific transcriptomic adaptations that support nutrient uptake, epithelial repair, immune response, and oxidative balance, thereby enhancing growth.
This study offers new insights into how broilers respond to dietary fiber supplementation at the transcriptomic level, supporting the strategic use of SB in sustainable poultry production.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE330nnn/GSE330384 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE330384 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1463760 ncbi.nlm.nih.gov/bioproject/PRJNA1463760 ↗
project · from NCBI GEO
- PubMed 42174444 pubmed.ncbi.nlm.nih.gov/42174444 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Gallus gallus
- From keywords
- Life Sciences
- Inferred from text
- Crop and pasture production 74%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE330384 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3004 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (74%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9031 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |