Key molecules and regulatory processes of lysine succinylation

Note

The abbreviations and full names of key molecules involved in this figure are as follows: 1. Metabolic intermediates and enzyme complexes: AKG (α-ketoglutarate); α-KGDHC (α-ketoglutarate dehydrogenase complex); Succinyl-CoA (succinyl coenzyme A); SUCL (succinate-CoA ligase) 2. Enzymes related to succinylation/desuccinylation: CoBb (prokaryotic desuccinylase, Sir2-like bacterial lysine deacetylase); SIRT5 (silent information regulator 5); SIRT7 (silent information regulator 7); HAT1 (histone acetyltransferase 1); HDAC1/2/3 (histone deacetylase 1/2/3); KAT2A (lysine acetyltransferase 2A) 3. Key target proteins and metabolic enzymes: CPS1 (carbamoyl-phosphate synthase 1); CPT1A (carnitine palmitoyltransferase 1A); ENO1 (enolase 1); Histone H3 (histone H3); OXCT1 (3-oxoacid CoA-transferase 1); PGAM1 (phosphoglycerate mutase 1).