Data · dataset · 2026
Investigation of antibacterial property and mode of action of medicinal plants against resistant pathogenic bacteria
Listed in ZivaHub and Deakin Research Online and DMU Figshare and UCL Research Data Repository — shown once because both records carry DOI 10.17034/32633559.v1
This project illustrates the antibacterial efficacy of crude aqueous infusions ofmedicinal plants against resistant pathogens including Methicillin-resistantStaphylococcus aureus (MRSA), Klebsiella pneumoniae, Acinetobacterbaumannii, Pseudomonas aeruginosa, and Escherichia coli.
Description
The plantinfusions of Rheum palmatum L., Arctium lappa L. and Paeonia suffructicosaAndr demonstrated the strongest anti-MRSA activity via multiple targets, withthe minimum inhibitory concentration (MIC) of 7.8 μg/mL.
While strongantibacterial activity was exhibited by Sanguisorba officinalis L., Cyrtomiumfortunei J.Smith, Smilax china L. and Cornus officinalis Siebold & Zuccaqueous infusions against Gram negative resistant bacteria, with disruption ofthe bacteria membrane and interference with the intracellular structures bymultiple targets. A combination of plant infusions and antibiotics providedenhanced antibacterial activity of antibiotics, resulting in a significant decreasein antibiotic MIC, providing a potential path to restoring pathogen susceptibilityto antibiotics.
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Furthermore, both in vitro and in vivo toxicity tests have beenconducted on these plant infusions, indicating their safety profile. It can beconcluded from the results that multi-targeted action of aqueous crudemedicinal plant infusions contained synergistic phytochemicals effectivelyinhibits ESKAPE strains, which further suggested that medicinal plants couldpotentially be used to treat infectious diseases caused by resistant pathogensas a viable alternative to antibiotics, and could be an effective approach in thecontrol of antibiotic resistance in the near future. <br><br>
Links
Where it is published
- DOI doi.org/10.17034/32633559.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Life Sciences · Life Sciences · Life Sciences · Life Sciences · Medicine & Health · Medicine & Health · Medicine & Health · Medicine & Health · Microbiology · Microbiology · Microbiology · Microbiology
Provenance · 4 source records, 20 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/32633559 | 10 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/32633559 | 10 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/32633559 | 10 d ago | JSON v1 |
| UCL Research Data Repository | oai:figshare.com:article/32633559 | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[field].anzsrc:group:3107 | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['microbiology'] |
| concepts[field].anzsrc:group:3107 | mapping · rdr ucl ac uk | vocabulary-mapper@1.0.0 | keywords['microbiology'] |
| concepts[field].anzsrc:group:3107 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['microbiology'] |
| concepts[field].anzsrc:group:3107 | mapping · figshare dmu ac uk | vocabulary-mapper@1.0.0 | keywords['microbiology'] |
| concepts[field].local:field:earth-environmental | mapping · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |