Data · dataset · 2023
Lecanicilliums A-F, Thiodiketopiperazine-class Alkaloids from the mangrove sediment-derived fungus Lecanicillium kalimantanense
Listed in ScienceDB
Six new thiodiketopiperazine-class alkaloids, lecanicilliums A-F (1-6), were isolated from the mangrove sediment-derived fungus Lecanicillium kalimantanense SCSIO41702, together with 13 known analogous (7-19).
Description
Compound 1 contained an unprecedented 6/5/6/5/7/6 cyclic system. Their structures were elucidated by spectroscopic analysis, and the absolute configurations were further determined by quantum chemical calculations electronic circular dichroism (ECD) spectra.
Biologically, 5, 7 and 16 displayed significant cytotoxicity against human lung adenocarcinoma cell line H1975 with IC50 values of 7.2~16.9 μM, and 5 showed antibacterial activity against five pathogens. Their structure-activity relationship is also discussed.
Links
Where it is published
- DOI doi.org/10.57760/sciencedb.09640 ↗
DOI / persistent id · from scidb cn
Catalogue records · 1
- OAI-PMH record scidb.cn/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=10.57760%2… ↗
metadata API · from scidb cn
Topics
- From keywords
- Earth & Environmental Science · Engineering · Humanities · Life Sciences · Social Science
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ScienceDB | 10.57760/sciencedb.09640 | 9 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:engineering | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:humanities | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:social-science | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| description | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/description |
| license | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/rights |
| publication_date | source · scidb cn | connector:scidb_cn@1.0.0 | |
| title | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/title |