<b>Particle geometry governs protein corona</b><b>-</b><b>mediated neutrophil hitchhiking for </b><b>enhanced tumor delivery</b>

Here we use sonication to transform compositionally identical SN38 dimeric prodrug nanoassemblies from spheres into rods with aspect ratios of 6, 9 and 40. Geometry remodelled the plasma protein corona and directed the nanoassemblies towards distinct transport routes.

Spheres and AR40 rods tent to recruit complement or acute-phase proteins and suffered from quick clearance in vivo, whereas AR9 rods enriched transport proteins, prolonging circulation but remaining largely confined to tumor perivascular regions. AR6 rods minimized complement deposition and enriched neutrophil‑associated proteins, resulting in sustained neutrophil hitchhiking, high tumor accumulation, and efficient delivery into the tumor parenchyma.