<p>Low-dose/high-stress exposure reduces body weight but does not cause anxiety or cognitive impairment in rats.</p>

No significant differences were found between groups. <b>(D) Elevated plus maze test.</b> The percentage of time spent in the open arms was analyzed (n = 12/group). GWI/LH-001 rats spent more time in the open arm when compared to control/LH-001 rats. <b>(E-F) Dark and light test.</b> Latency to enter the dark chamber (E) and percent of time spent in the light chamber (F) were assessed (n = 11–12/group). No significant differences were found between groups. <b>(G-H) Novelty-suppressed feeding test.</b> Amount of food consumed (G) and latency to begin feeding (H) were analyzed (n = 11–12/group).

No significant differences were found between groups. <b>(I, J) Recognition memory test.</b> Discrimination index scores for novel object location (I) and novel object recognition (J) were calculated (n = 11–12/group). No significant differences were found between groups. <b>(K-L) Barnes maze test.</b> Latency to find the escape hole (K) and time spent in the target quadrant (L) during the initial training phase were analyzed (n = 12/group).

GWI/vehicle rats found the target hole more quickly when compared to control/LH-001 rats. <b>(M-N) Barnes maze re-training.</b> Latency to the new escape hole (M) and time spent in the new target quadrant (N) were analyzed one week later (n = 12/group). No significant differences were found between groups. <b>(O) Barnes maze memory recall.</b> Time spent in the original target quadrant during the re-training phase was analyzed (n = 12/group).

Overall, no general trend for anxiety-like phenotypes or cognitive deficits with increasing stress was found. *<i>p</i> < 0.05, ***<i>p</i> < 0.001.</p>