Data · dataset · 2026
<p>Effect of HbAA, HbAC, HbAS, HbSS and HbSC on SC by <i>iv</i>SCAs.</p>
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<p><b>(A)</b> Experimental design of <i>in vitro</i> SC assays (<i>iv</i>SCAs) using the NF54<i>-gexp02-Tom P. falciparum</i> line.
Description
Tightly synchronized schizonts (Generation -1) were allowed to reinvade red blood cells (RBCs) of different HBB genotypes, and ring stages (0-5 hpi) were cultured under non-inducing (+Choline) and inducing (-Choline) conditions. Parasite development was assessed by flow cytometry at 35-40 hpi (Generation 0) and 25-30 hpi/35-40 hpi (Generation 1).
SCRs were measured by flow cytometry at 25-30 hpi and 35-40 hpi (Generation 1). SCRs by HBB genotype at 35-40 hpi (Generation 1) in <b>(B)</b> +Choline cultures and (C) in -Choline cultures. <b>(D)</b> Proportion of asexual and gametocyte stages and total parasitemia by HBB genotype at 35-40 hpi (Generation 1) in +Choline cultures. <b>(E)</b> Reticulocytes percentage by HBB genotype. Statistical tests: B, C and E, Beta-binomial GLMs with Bonferroni correction for pairwise comparisons.
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Significant <i>p</i>-values are shown as: <i>p</i> < 0.05*, <i>p</i> < 0.01**, <i>p</i> < 0.001***; non-significant <i>p</i>-values as: ns. Abbreviations: CTRL, control sample; GLMs, Generalized linear models; Hb, hemoglobin; HBB, human hemoglobin beta; Hpi, hours post-invasion; SC, sexual conversion; SCR, sexual conversion rates. Panel A was created in BioRender.
Yasmina, <b>D.</b> (2026) <a href="BioRender.com/ew8vbur" target="_blank">BioRender.com/ew8vbur</a>.</p>
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- DOI doi.org/10.1371/journal.ppat.1014542.g002 ↗
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Topics
Provenance · 1 source records, 14 field assertions
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|---|---|---|---|
| ZivaHub | oai:figshare.com:article/34027136 | 11 d ago | JSON v1 |
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