Omics · study · 2026
Transcriptomic responses following AMC-EVs treatment in subfertile mares
Listed in NCBI GEO
Equine endometrial dysfunction is a major cause of subfertility in mares, and although the Kenney and Doig classification is widely used for prognosis, it does not capture the underlying molecular alterations.
Description
In this study, the early transcriptomic effects of intrauterine administration of amniotic membrane-derived extracellular vesicles (AMC-EVs) were investigated in subfertile mares using a paired pre- and post-treatment design.
RNA sequencing revealed significant gene expression changes (FDR < 0.05) following treatment, including upregulation of pathways related to receptor-mediated signaling, immune response, and vesicular transport, alongside downregulation of metabolic and RNA-processing pathways. These findings indicate that AMC-EVs induce early transcriptional reprogramming in the equine endometrium, suggesting a potential role in modulating molecular processes associated with endometrial function.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE328nnn/GSE328832 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE328832 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1456617 ncbi.nlm.nih.gov/bioproject/PRJNA1456617 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE328832 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |