Diagnostic performance of host protein signatures as a triage test for active pulmonary TB [data]

In contrast, more sensitive molecular tests are less suitable for placement at primary care level in low resource settings. In order to meet the WHO End TB targets new diagnostic approaches are urgently needed to find the missing undiagnosed cases.

Proteomics-derived blood host biomarkers have been explored because protein detection technologies are suitable for the point-of-care setting and could meet cost targets. This study aimed to find a biomarker signature that fulfills WHO’s target product profile (TPP) for a TB screening. 12 blood-based protein biomarkers from three sample populations (Vietnam, Peru, South Africa) were analyzed individually and in combinations via advanced statistical methods and machine learning algorithms.