Imaging · dataset · 2026
DSPE-Based Ligand-Cross-Linked Lipid Nanoparticles for BBB/BBTB Transport and Glioma Targeting
Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.1021/acsnanomed.6c00185.s001
Insufficient drug accumulation at intracranial tumor sites remains a major obstacle to effective glioma therapy, primarily due to restricted transport across the blood–brain barrier (BBB)/blood–brain tumor barrier (BBTB) and limited active targeting to glioma cells.
Description
Here, we report DSPE-based ligand-cross-linked lipid nanoparticles (DBLC LNPs) that integrate lipid-interface engineering, ligand cross-linking, and sequential glioma targeting within a single nanoparticle platform.
In this design, maltobionic acid (MA)-functionalized DSPE was incorporated to promote glucose transporter 1 (GLUT1)-mediated BBB/BBTB transport, while 3-(propionamido)phenylboronic acid (PAPBA)-functionalized DSPE was introduced to recognize sialic acid-containing glycans on glioma cell surfaces. Compared with many complex multifunctional brain-tumor nanocarriers, this DSPE-based lipid-interface design introduces transport and recognition through defined lipid-ligand conjugates, thereby reducing synthetic complexity while maintaining formulation tunability and cargo-loading flexibility.
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Microfluidic technology further enabled controlled and reproducible preparation of DBLC LNPs, supporting their formulation compatibility and translational potential. In an orthotopic glioma model, vincristine (VCR)-loaded DBLC LNPs significantly suppressed glioma growth and prolonged survival. Magnetic resonance imaging (MRI)-based 3D reconstruction analysis of brain tumor further showed that DBLC LNPs@VCR inhibited tumor growth more effectively than free VCR, with tumor volume more than 6-fold lower than that in the free VCR group.
Together, this study establishes a DSPE-based ligand-cross-linked LNP platform that combines sequential BBB/BBTB transport, drug-loading capacity, and formulation compatibility to improve therapeutic delivery for glioma treatments.
Links
Where it is published
- DOI doi.org/10.1021/acsnanomed.6c00185.s001 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Astronomy & Astrophysics · Astronomy & Astrophysics · Astronomy & Astrophysics · Biochemistry and cell biology · Biochemistry and cell biology · Biochemistry and cell biology · Cancer · Cancer · Cancer · Chemistry · Chemistry · Chemistry · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Engineering · Engineering · Engineering · Genetics · Genetics · Genetics · Life Sciences · Life Sciences · Life Sciences · Magnetic resonance imaging · Magnetic resonance imaging · Magnetic resonance imaging · Medicine & Health · Medicine & Health · Medicine & Health
- Inferred from text
- Imaging 75%
Provenance · 3 source records, 36 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/34044504 | 5 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/34044504 | 5 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/34044504 | 5 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[disease].local:disease:cancer | mapping · figshare dmu ac uk | vocabulary-mapper@1.0.0 | keywords['Cancer'] |
| concepts[disease].local:disease:cancer | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Cancer'] |
| concepts[disease].local:disease:cancer | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['Cancer'] |
| concepts[field].anzsrc:group:3101 | mapping · figshare dmu ac uk | vocabulary-mapper@1.0.0 | keywords['Cell Biology'] |
| concepts[field].anzsrc:group:3101 | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['Cell Biology'] |
| concepts[field].anzsrc:group:3101 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Cell Biology'] |
| concepts[field].anzsrc:group:3105 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Genetics'] |
| concepts[field].anzsrc:group:3105 | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['Genetics'] |
| concepts[field].anzsrc:group:3105 | mapping · figshare dmu ac uk | vocabulary-mapper@1.0.0 | keywords['Genetics'] |
| concepts[field].local:field:astronomy | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:astronomy | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:astronomy | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:engineering | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:engineering | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:engineering | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[modality].local:modality:imaging | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:mri | mapping · figshare dmu ac uk | vocabulary-mapper@1.0.0 | keywords['magnetic resonance imaging'] |
| concepts[modality].local:modality:mri | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['magnetic resonance imaging'] |
| concepts[modality].local:modality:mri | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['magnetic resonance imaging'] |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/rights |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |