Supplementary Materials for Reviewers

Top 50 reporting odds ratios (ROR) with 95% confidence intervals (CI) for positive signals of non-psychiatric adverse events reported among isotretinoin users. Supplementary Figure 4. Stratification analysis of reporting odds ratios (ROR) with 95% confidence intervals (CI) for psychiatric disorders among isotretinoin users.

Supplementary Figure 5. Reporting odds ratio lower bounds (RORL) for 50 preferred terms (PTs) across the overall sample and different strata. Tables: Supplementary Table 1.

Calculation of reporting odds ratio (ROR). Supplementary Table 2. A rating scale assessing clinical priority of disproportionality signals.

Supplementary Table 3. Top 50 drugs reported in psychiatric adverse event reports ranked by number of reporters among 2772 drugs. Supplementary Table 4.

Top 50 co-medications ranked by number of reported cases. Supplementary Table 5. Classification of 96 psychiatric adverse events reported among isotretinoin users.

Supplementary Table 6. Time-to-onset analysis for important signals across overall population and different strata.