The Causal Relationship Between Psoriasis and Urolithiasis: A Two-Sample Bidirectional Mendelian Randomization Study

A sensitivity analysis was conducted using the leave-one-out method, while a multiplicity analysis was performed with the MR-Egger method. Additionally, Cochran Q was employed to detect heterogeneity. Furthermore, reverse Mendelian randomization was conducted to examine the potential causal relationship between urolithiasis and psoriasis.Results The results of the MR analysis showed a positive causal association between psoriasis and urolithiasis [OR=1.023, 95%CI(1.0015,1.0447), P=0.0357]; the results of the reverse MR analysis showed that urolithiasis did not increase the risk of psoriasis [OR=1.0187, 95%CI(0.9084,1.1421), P=0.7527].

The results of the sensitivity analyses were robust, the funnel plots were not biased and there was no heterogeneity, pleiotropy or reverse causality in the results (all P>0.05).Conclusion The results of this study provide evidence for a causal association between psoriasis and the development of urolithiasis, and that psoriasis may increase the risk of developing urolithiasis, but no evidence was found that urolithiasis contributes to the increased risk of psoriasis.