Supporting Data and Code for Context-Dependent Pharmacovigilance Reporting Phenotypes Across Pulmonary Arterial Hypertension Therapies

<p dir="ltr"><b>This repository contains supporting derived data, machine-readable tables, analysis materials, and R code associated with the study “Quantifying context dependence of pharmacovigilance reporting phenotypes across pulmonary arterial hypertension therapies: an indication-matched FAERS study.”</b></p><p dir="ltr">The study analyzed publicly available U.S. FDA Adverse Event Reporting System (FAERS) reports accessed through the openFDA Drug Adverse Event resources, with a frozen data cut of 30 June 2026.

The analytic framework used an indication-matched pulmonary arterial hypertension (PAH) reporting universe and evaluated context dependence through conventional disproportionality analyses, sensitivity persistence, sequential persistence, treprostinil route localization, whole-profile reporting divergence, and selected regulatory-time analyses.</p><p dir="ltr">The repository includes derived analytical tables, figure-generation scripts, supplementary analysis scripts, locked inputs where available, quality-control files, manifests, and archived analysis packages used to support the reported results.