Imaging · study · 2026
Lipid-Associated Macrophage Polarization Drives Chronic Xenograft Fibrosis via APOE-SDC2 Signaling
Listed in NCBI GEO
Chronic injury of xenografted kidneys, characterized by interstitial fibrosis and tubular atrophy, remains a critical barrier to clinical translation.
Description
We employed integrated single-nucleus RNA sequencing, spatial transcriptomics, and plasma proteomics on pig-to-cynomolgus monkey kidney xenografts. We identified lipid-associated macrophage polarization and macrophage-fibroblast crosstalk via APOE-SDC2 signaling as central mechanisms driving fibrosis.
Combined immunosuppression suppressed this pathway and prevented injury progression.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE311nnn/GSE311717 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE311717 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1370825 ncbi.nlm.nih.gov/bioproject/PRJNA1370825 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Other · Sus scrofa
- From keywords
- Life Sciences
- Inferred from text
- Mass spectrometry 65% · RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 11 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE311717 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:mass-spectrometry | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9823 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |