Omics · study · 2026
Quantitative characterization of the aging intestine secretome reveals novel secreted proteins that act in the extracellular space to regulate lifespan
Listed in NCBI GEO
Secreted proteins are essential to modulate the extracellular space and communicate to distal cells or tissues.
Description
But the importance of extracellular proteins in aging has been understudied. Here we use proximity labeling followed by quantitative proteomics to systematically characterize the intestine and neuron secretome in C. elegans.
We identify many previously unknown intestine secreted proteins that change with age, and we validate the secretion of these proteins by in vivo cell biology. One of these secreted proteins, ACP7, is well conserved in humans. Overexpressing ACP7 extends lifespan in a secretion-dependent manner, and we find that ACP7 acts as a phosphatase in the extracellular space.
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Finally, we identify additional proteins along the secretion pathway that regulate lifespan, including VAPA – a protein localized to small secretory vesicles in the intestine. Our systematic characterization of tissue-specific secretome during aging uncovers novel proteins that impact lifespan and highlights the role of extracellular enzymes in aging.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE307nnn/GSE307266 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307266 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1315043 ncbi.nlm.nih.gov/bioproject/PRJNA1315043 ↗
project · from NCBI GEO
- PubMed 42658673 pubmed.ncbi.nlm.nih.gov/42658673 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Caenorhabditis elegans · Expression profiling by high throughput sequencing
- From keywords
- Life Sciences
- Inferred from text
- Biochemistry and cell biology 73% · Mass spectrometry 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE307266 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3101 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (73%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:mass-spectrometry | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:6239 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |