<p>Antigenicity of bat sarbecoviruses using SARS-CoV-2 polyclonal convalescent sera.</p>

These include samples from individuals following infection with the wildtype (WT), Alpha, Gamma, Delta, or Omicron BA.1 variants, either confirmed by PCR or assumed based on epidemiological data. The sample set also includes WHO International Standards provided by MRHA (NIBSC), pooled vaccinee plasma (low and high titre) and negative plasma, pooled from individuals pre-2019.

Information about the COVID-19 standards and reagents can be found here: WHO/BS/2022.2427: Establishment of the 2nd WHO International Standard for anti-SARS-CoV-2 immunoglobulin and Reference Panel for antibodies to SARS-CoV-2 variants of concern. <b>(B)</b> Heatmap showing the log (IC₅₀) values of neutralisation (the dilution at which there was a 50% reduction in luciferase activity) of SARS-CoV-2, BANAL-20-52, BANAL-20-103, BANAL-20-236, Rs4231, WIV-1, RhGB07, Rc-o319 and BA.1 viruses in the presence of the MHRA (NIBSC) reference reagents.